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. 2016 Dec 22;8:315. doi: 10.3389/fnagi.2016.00315

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Copyright © 2016 Rodriguez-Callejas, Fuchs and Perez-Cruz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemistry for AT-100 in different brain regions of marmoset. Adolescent animals (A–D) presented a light phosphorylation of tau residues Thr212 and Ser214 in all regions analyzed. Adult subjects (E–H) showed same pattern of immunoreactivity. Old individuals (I–L) had a stronger labeling as AT100-ir appears in cytoplasm, but also as inclusions in the nucleus of the cells. In the aged individuals (M–P) AT100-ir increased in all brain regions of the brain analyzed (cytoplasmic and nuclear inclusions). Inclusions indicated by arrows. Scale bar 50 μm.