Table 1.

Mean pharmacokinetic parameters of S 38093 (0, 0.1, and 1.0 mg/kg) and Donepezil (0.3 mg/kg), given alone or in combination in middle-aged mice (five groups, n = 3/group).

	Dose	0	0.1		1
S 38093	AUC (ng.h/mL)	–	9.56	3.69	92.40	53.90
	Cmax (ng/mL)	–	3.04	1.27	55.6	36.30
	Tl/2(h)	–		1.51	2.37	1.54
	Tmax(ll)	–	2.0	0.5	0.5	0.5
	Dose	0.3	0	0.3	0	0.3
Donepezi	AUC (ng.h/mL)	2.79	–	0.90	–	1.55
	Cmax (ng/mL)	0.96	–	0.48	–	1.11
	Tmax(ll)	1.0	–	0.5	–	0.5

The PK parameters of the co-administration of S 38093 (0.1 and 1.0 mg/kg) with Donepezil (0.3 mg/kg) are in the gray columns.