Figure 2.

Removal of photoreceptor to ON-BC signaling leaves photopic OFF RGC responsivity intact. (A) Mean whole field response of all cells before (blue) and after (red) L-AP4 under photopic (row 2) and scotopic (row 3) conditions. ON responses are abolished while OFF responses are intact under photopic conditions while both ON and OFF responses are lost under scotopic conditions. (B) Example photopic space-time STA for a single cell before (blue) and after L-AP4 (red). (Ci) Scores from principal components analysis (PC1) were used to identify ON and OFF cells. (ii) STA waveforms from the two groups identified. (iii) ON-OFF index identified from whole field data. (D) Example scotopic space-time STA for a single cell before and after L-AP4.