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. 2016 Dec 5;5(12):e274. doi: 10.1038/oncsis.2016.73

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Development of ICC in AKT/Jag1 mice. (a) Left panel: 8 weeks post-injection the liver of AKT/Jag1 mice shows the presence of small cystic lesions (indicated by arrows) appearing paler than the surrounding liver parenchyma. These lesions increase in size and number 11 weeks post injection (middle panel), occupying the whole liver by 14 weeks post injection (right panel). (b) Left panel: at microscopic level the liver of AKT/Jag1 mice is occupied by numerous lipid-rich preneoplastic lesions equivalent to those detected in AKT mice. However, some cholangiocellular lesions (indicated by arrows) start to emerge. At higher magnification, these lesions are characterized by the presence of solid parts and pseudoglandular formations (the latter indicated by asterisks). With time these lesions occupy the liver parenchyma and tend to form large cysts (middle and right panel). Original magnifications in b: × 40 and × 200.