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. 2016 Dec 12;5(12):e278. doi: 10.1038/oncsis.2016.78

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Loss of Hif1α impairs hepatic metastasis and resistance toward anoikis state. (a–b) Representative H&E staining pictures (a) and metastasis area calculation (b) reveal decreased metastatic foci after portal vein injection of shHif1α cells as compared with shControl cells. (c) Anoikis assay shows diminished cell survival in the shHif1α cells under anchorage-independent conditions. (d) Western blot and quantified measurements show expression of cleaved-caspase 3 in shControl or shHif1α cells under anchorage-dependent and -independent conditions. The data were a result of three independent experiment. An unpaired t-test was used for determining statistical significance. *P<0.05. See Supplementary Materials and Methods.