Pfam domain enrichment in protein sets of Symbiodinium microadriaticum, Symbiodinium minutum, and Symbiodinium kawagutii (A) in comparison to 16 reference eukaryotic genomes, (B) in comparison to other dinoflagellate transcriptomes, (C) among Symbiodinium genomes. Rows indicate distinct Pfam domains. Domain enrichment was estimated via Fisher’s exact test on domain ratios, colors represent z-scores, and samples were clustered by Euclidean distance. Species names providing reference genomes are abbreviated as per the following: Symbiodinium kawagutii (Skav), Symbiodinium minutum (Smin), Symbiodinium microadriaticum (Smic), Emiliania huxleyi (Ehux), Thalassiosira pseudonana (Tpseu), Chlamydomonas reinhardtii (Cre), Guillardia theta (Gthe), Capsaspora owczarzaki (Cow), Trypanosoma brucei gambiense (Tgb), Tetrahymena thermophila (Ttherm), Plasmodium falciparum (Pfl), Arabidopsis thaliana (Ath), Amphimedon queenslandica (Aqu), Stylophora pistillata (Spis), Trichoplax adhaerens (Tad), Lottia gigantea (Lgi), Daphnia pulex (Dpu), Caenorhabditis elegans (Cel), Homo sapiens (Hsa). Species names providing reference transcriptomes are abbreviated as per the following: Symbiodinium microadriaticum strain Kb8 (SmicKb8), Symbiodinium minutum strain Mf1.05b (SminMf1.05b), Symbiodinium kawagutii (Skaw.TS), Karenia brevis strain SP1 (KbrevSP1), Lingulodinium polyedrum (Lingu), Prorocentrum minimum (Proro), Amphidinium carterae (Amp), and Crypthecodinium cohnii (Crypt). A complete list of pfam domains and pfam annotations for all analyses are accessible in the supplement (Dataset S1.2, Dataset S1.3, Dataset S.14, Supplemental Information, Table S5).