. 2016 Dec 22;6:39672. doi: 10.1038/srep39672

Table 2. Results for subgroup analyses.

Subgroup	Included study	OA patients	CVD patients	Total participants	RR (95% CI)	P
Study design
Retrospective	Refs ⁴,⁹,¹²,¹⁴,¹⁶	61,779	15,662	284,358	1.15 (0.95–1.38)	0.147
Prospective	Refs ⁵, ⁶, ⁷, ⁸,¹⁰,¹¹,¹³,¹⁵,¹⁷,¹⁸	19,132	13,551	74,586	1.30 (1.16–1.46)	<0.001
OA site
Hand	Refs ⁴,⁶,⁸,¹¹,¹⁸	6,587	3,256	15,728	1.03 (0.85–1.25)	0.749
Knee	Refs ⁶,¹¹,¹⁷,¹⁸	1,593	2,106	7,796	1.30 (1.00–1.69)	0.047
Hip	Refs ⁶,⁷,¹⁸	1,374	3,956	13,968	1.23 (1.11–1.38)	<0.001
OA confirmation
Radiographic	Refs ⁴, ⁵, ⁶, ⁷, ⁸,¹¹,¹³,¹⁷	8,321	5,116	25,362	1.23 (1.02–1.48)	0.028
Clinical	Refs ⁵,⁶,¹¹	579	1,309	6,037	1.47 (0.91–2.39)	0.118
Outcome type
IHD	Refs ⁴,⁵,⁹,¹⁰,¹⁴, ¹⁵, ¹⁶,¹⁸	71,207	8,480	177,253	1.33 (1.20–1.46)	<0.001
Stroke	Refs ⁴,⁵,¹⁴, ¹⁵, ¹⁶,¹⁸	59,429	3,469	151,321	1.11 (0.96–1.29)	0.16
CHF	Refs ⁵,⁹,¹⁴,¹⁵,¹⁸	27,516	3,389	87,500	1.40 (1.13–1.73)	0.002
Cardiovascular death	Refs ⁷,⁸,¹¹,¹³,¹⁷,¹⁸	5,143	2,978	16,109	1.53 (1.27–1.84)	<0.001