Table 2. Comparison of GPS-PAIL with ASEB11,32, by using 158 non-human HAT-specific sites of 45 proteins as the testing data set.
HAT | Positivea | Negative | Pr | Sn | Sp | |
---|---|---|---|---|---|---|
GPS-PAIL (LOO) | CREBBP | 167 | 1719 | 16.12 | 38.32 | 80.63 |
EP300 | 411 | 3525 | 22.81 | 50.61 | 80.03 | |
HAT1 | 10 | 110 | 62.50 | 100.00 | 94.55 | |
KAT2A | 32 | 265 | 30.56 | 68.75 | 81.13 | |
KAT2B | 69 | 954 | 17.17 | 49.28 | 82.81 | |
KAT5 | 28 | 531 | 39.29 | 39.29 | 96.80 | |
KAT8 | 6 | 177 | 33.33 | 83.33 | 94.35 | |
GPS-PAIL (Testing) | CREBBP | 81 | 405 | 28.32 | 39.51 | 80.00 |
EP300 | 85 | 605 | 25.85 | 44.71 | 81.98 | |
HAT1 | 5 | 33 | 100.00 | 100.00 | 100.00 | |
KAT2A | 37 | 430 | 19.23 | 54.05 | 80.47 | |
KAT2B | 40 | 133 | 47.92 | 57.50 | 81.20 | |
KAT5 | 4 | 7 | 100.00 | 100.00 | 100.00 | |
KAT8 | 4 | 139 | 36.36 | 100.00 | 94.96 | |
ASEB (Testing) | CREBBP/EP300 | 107 | 771 | 22.61 | 42.06 | 80.03 |
KAT2A/KAT2B | 73 | 522 | 23.08 | 41.10 | 80.84 |
For convenience, the LOO results of GPS-PAIL on our training data set were also provided. a. Positive, the number of positive sites.