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. 2016 Dec 22;6:39730. doi: 10.1038/srep39730

Figure 3. Neutralisation sensitivity of chimeric L1L2 PsV to HPV vaccine-induced antibodies.

Figure 3

Colour indicates L1L2 PsV constructs: HPV31 (white), HPV35 (grey), HPV31 L1 backbone with HPV35 loop switches (blue) and HPV35 L1 backbone with HPV31 loop switches (red). Bar graph represents the neutralisation GMT of n = 36 HPV vaccine sera (Cervarix® n = 19; Gardasil® n = 17), all of which were tested against HPV31, HPV35 and the chimeric L1L2 PsV. Error bars represent GMT neutralisation titre 95% CI. p values obtained using the Wilcoxon paired signed-rank test represent differences in neutralisation titre between either the HPV31 PsV and the chimeric PsV with a HPV31 backbone or the HPV35 PsV and the chimeric PsV with a HPV35 backbone.