Figure 4. Seropositivity does not influence CXCR5⁺Th17 cell frequency.

(a) Frequency of CXCR5⁺Th17 cells (gated as CCR6⁺ cells out of CXCR5⁺ CD4⁺CD45RO⁺ cell population) in CCP negative and CCP positive subjects in cohort 2 as described in Table 1. (b) Correlation between CCP levels in serum and CXCR5⁺Th17 cells at baseline prior to therapy initiation. (c) Correlation between RF levels in serum and CXCR5⁺Th17 cells at baseline prior to therapy initiation. For each graph, each dot represents a unique individual in the study.