Figure 1.

Astrogliosis following focal herpes zoster encephalitis. A. MRI of brain of case 1. The site of focal herpes zoster encephalitis in the temporal lobe is marked with an arrow. G=gray matter; W=white matter. B. Activated astrocyte in the brain biopsy. The uninfected astrocyte is immunolabeled with antibody to GFAP. C. Focus of VZV infection in temporal lobe. A 3-dimensional rendering of a focus of VZV-infection was made from numerous confocal images by the Imaris software program. Green=astrocytes infected with VZV and immunolabeled with antibody to the viral gH protein; red= uninfected astrocytes labeled with antibody to GFAP; blue = nuclei. Also see reference 17.