Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jul 29;62(6):537–545. doi: 10.1262/jrd.2016-083

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

©2016 Society for Reproduction and Development

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

PMC Copyright notice

Fig. 1. — Schematic illustration of the molecular and epigenetic mechanism underlying hypothalamic Kiss1 expression. (A) In the anteroventral periventricular nucleus (AVPV), estrogen-estrogen receptor α (ERα) complex induces Kiss1 expression via histone acetylation of the Kiss1 promoter and chromatin loop formation between the Kiss1 promoter region and the 3'-downstream region. (B) In the arcuate nucleus (ARC), histone acetylation of the Kiss1 promoter and chromatin loop formation between the Kiss1 promoter region and the 5'-upstream region via unknown transcriptional factor(s) seems to be involved in Kiss1 expression. Ac, histone acetylation.