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Levels of progesterone per cumulus-oocyte complex (COC) at 24 h of in vitro maturation (hIVM). Recombinant human proMMP9 (hMMP9) was supplemented during the last 6 (experiment 1; A) or 12 (experiment 2; B) hours of maturation to cumulus-oocyte complexes matured at 38.5 or 41.0ºC (first 12 h only and then transferred to 38.5ºC). ABC Different letters denote statistical difference within an experiment. n.a., not applicable.
