Table 6b.
Joint effect of smoking and GRS on VTE risk.
| Never Smokers | Ever Smokers | |
|---|---|---|
| Low GRS | 2,549 Controls | 2,915 Controls |
| 134 Cases | 189 Cases | |
| OR = 1.00 (REF) | OR = 1.19 | |
| 95% CI: 0.91-1.56 | ||
| Medium GRS | 2,488 Controls | 2,986 Controls |
| 152 Cases | 237 Cases | |
| OR = 1.31 | OR = 1.65 | |
| 95% CI: 0.99-1.72 | 95% CI: 1.28-2.13 | |
| High GRS | 2,591 Controls | 2,864 Controls |
| 249 Cases | 306 Cases | |
| OR = 2.22 | OR = 2.41 | |
| 95%CI: 1.74-2.86 | 95%CI: 1.90-3.08 | |
P-interaction = 0.60
ORs adjusted by age, cohort and platform
Weighted GRS, tertiles based on controls only