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. Author manuscript; available in PMC: 2017 Sep 27.
Published in final edited form as: Thromb Haemost. 2016 Jun 16;116(4):705–713. doi: 10.1160/TH16-02-0172

Table 6b.

Joint effect of smoking and GRS on VTE risk.

Never Smokers Ever Smokers

Low GRS 2,549 Controls 2,915 Controls
134 Cases 189 Cases
OR = 1.00 (REF) OR = 1.19
95% CI: 0.91-1.56

Medium GRS 2,488 Controls 2,986 Controls
152 Cases 237 Cases
OR = 1.31 OR = 1.65
95% CI: 0.99-1.72 95% CI: 1.28-2.13

High GRS 2,591 Controls 2,864 Controls
249 Cases 306 Cases
OR = 2.22 OR = 2.41
95%CI: 1.74-2.86 95%CI: 1.90-3.08

P-interaction = 0.60

ORs adjusted by age, cohort and platform

Weighted GRS, tertiles based on controls only

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