Table 1.
PDXs established in first (P0) or later passages classified according to the 2008 World Health Organization Classification1. See also Figure S1 and Movie S1.
| ≥P0 | ≥P1 | |
|---|---|---|
| Acute myeloid leukemia | 71 | 40 |
|
| ||
| AML with MDS-related changes | 11 | 6 |
| AML with inv(16) CBFB-MYH11 | 1 | 0 |
| AML with t(9;11) MLLT3-MLL | 1 | 1 |
| AML with MLL rearrangement (details N/A) | 2 | 2 |
| Therapy-related AML | 1 | 1 |
| AML with recurrent gene mutations | 16 | 8 |
|
| ||
| FLT3 ITD+/−TKD and NPM1 mutated | 9 | 6 |
| FLT3 ITD only, NPM1 unknown | 2 | 1 |
| FLT3 ITD only, NPM1 negative | 1 | 1 |
| NPM1 mutated only | 3 | 0 |
| CEBPA mutated only | 1 | 0 |
| AML NOS | 16 | 10 |
|
| ||
| Acute myelomonocytic leukemia | 7 | 3 |
| Acute monocytic leukemia | 1 | 1 |
| No specific subcategory | 8 | 6 |
| Blastic plasmacytoid dendritic cell neoplasm | 9 | 8 |
| Subclassification pending annotation | 14 | 4 |
|
| ||
| Myelodysplastic syndrome | 1 | 1 |
|
| ||
| Refractory cytopenia with multilineage dysplasia | 1 | 1 |
|
| ||
| Acute lymphoid leukemia | 144 | 74 |
|
| ||
| B-ALL NOS | 53 | 28 |
| B-ALL with t(12;21) TEL-AML1 (ETV6-RUNX1) | 17 | 3 |
| B-ALL with t(9;22) BCR-ABL1 | 16 | 6 |
| B-ALL with t(v;11q23) MLL rearranged | 12 | 7 |
| B-ALL with t(1;19) E2A-PBX1 (TCF3-PBX1) | 3 | 1 |
| B-ALL with hypodiploidy | 6 | 1 |
| B-ALL with hyperdiploidy | 4 | 0 |
| T-ALL | 32 | 28 |
| Subclassification pending annotation | 1 | 0 |
|
| ||
| Acute leukemia of ambiguous lineage | 4 | 3 |
|
| ||
| Mixed phenotype acute leukemia with t(v;11q23) MLL rearranged | 2 | 2 |
| Mixed phenotype acute leukemia with t(9;22) BCR-ABL1 | 1 | 0 |
| B/myeloid acute leukemia | 1 | 1 |
|
| ||
| Mature B-cell neoplasms | 17 | 13 |
|
| ||
| Mantle cell lymphoma | 6 | 4 |
| DLBCL NOS | 4 | 4 |
| Follicular lymphoma | 3 | 2 |
| B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL | 2 | 2 |
| Extranodal marginal zone lymphoma | 1 | 1 |
| Subclassification pending annotation | 1 | 0 |
|
| ||
| Mature T- and NK-cell neoplasms | 9 | 7 |
|
| ||
| Angioimmunoblastic T-cell lymphoma | 3 | 2 |
| Anaplastic large cell lymphoma, ALK positive | 2 | 2 |
| Anaplastic large cell lymphoma, ALK negative | 1 | 1 |
| Adult T-cell leukemia/lymphoma | 1 | 1 |
| Extranodal NK/T-cell lymphoma | 1 | 1 |
| Primary cutaneous CD30 positive T-cell lymphoproliferative disorder | 1 | 0 |
|
| ||
| Hodgkin Lymphoma | 1 | 0 |
|
| ||
| Subclassification pending annotation | 1 | 0 |
|
| ||
| All Diagnoses | 248 | 138 |