Table 1.
Comparison of Clinical Data of Subjects with Diabetes With and Without Diabetic Peripheral Neuropathy Defined by the Neuropathy Disability Score and Control Subjects
| Control subjects | No neuropathy | Neuropathy | |
|---|---|---|---|
| n | 70 | 41 | 33 |
| Age | 41.8 ± 1.63*** | 44.3 ± 2.19 | 64.1 ± 1.79*** |
| Duration of diabetes | — | 23.3 ± 2.03 | 37.6 ± 3.2*** |
| BP-sys (mm Hg) | 122.8 ± 2.87*** | 129.9 ± 3.1 | 147.9 ± 4.78** |
| BMI (kg/m2) | 25.8 ± 0.79* | 27.6 ± 0.87 | 28.4 ± 0.8 |
| HbA1c (%) | 5.29 ± 0.12*** | 7.5 ± 0.18*** | 7.9 ± 0.26 |
| HbA1c (mmol/mol) | 34.3 ± 1.35*** | 59.1 ± 1.97*** | 62.6 ± 2.82*** |
| NerveCheck VPT | 8.6 ± 0.37*** | 6.4 ± 0.75** | 2.1 ± 0.6*** |
| NerveCheck CPT | 5.9 ± 0.07*** | 5.5 ± 0.22* | 3.2 ± 0.46*** |
| NerveCheck WPT | 4.7 ± 0.25*** | 5.7 ± 0.15** | 2.5 ± 0.4*** |
| PMNCV (m/s) | 49.6 ± 0.66*** | 42.9 ± 0.88*** | 36.6 ± 1.6** |
| SNCV (μV) | 50.9 ± 0.77*** | 44.2 ± 0.92*** | 35.9 ± 1.4*** |
| SNAP (m/s) | 20.5 ± 1.7*** | 12.3 ± 1.02*** | 5.1 ± 1.12*** |
| CNFD (No./mm2) | 28.8 ± 0.92*** | 22.9 ± 1.3** | 14.2 ± 1.6*** |
| IENFD (No./mm) | 10.9 ± 0.8*** | 8.05 ± 0.7* | 3.8 ± 0.75** |
Data are mean ± standard error of the mean, P-values are derived from unpaired t-test: *P ≤ 0.05, **P ≤ 0.001, ***P ≤ 0.0001, The P-values for comparing those with versus without DPN are in the left column, no DPN versus controls in the middle column, and DPN versus controls in the right column.
BMI, body mass index; CNFD, corneal nerve fiber density; CPT, cold perception threshold; DPN, diabetic peripheral neuropathy; HbA1c, glycated hemoglobin; IENFD, intraepidermal nerve fiber density; PMNCV, peroneal motor nerve conduction velocity; SNAP, sural nerve action potential; SNCV, sural nerve conduction velocity; VPT, vibration perception threshold; WPT, warm perception threshold.