Table 1.
Changes in Cardiovascular Variables During Blinded Titration
| Baseline | Week 8 | Visit effect | ||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Group | Mean (SD) | Mean (SD) | F df | P | All group effects | F df | P |
| Heart rate | GUAN-IR | 79.4 (10.9) | 73.8 (14.0) | 15.8 1/54 | 0.0002 | Visit | 0.2 1/170 | 0.6 |
| DMPH | 79.8 (11.0) | 81.4 (13.6) | 1.1 1/59 | 0.3 | Group | 2.8 2/208 | 0.07 | |
| COMB | 78.5 (10.9) | 81.2 (13.9) | 2.6 1/57 | 0.1 | Visit × Group | 8.3 2/170 | 0.0004 | |
| BP systolic | GUAN-IR | 109.1 (8.6) | 105.2 (11.6) | 7.0 1/54 | 0.01 | Visit | 2.5 1/170 | 0.1 |
| DMPH | 109.6 (8.7) | 115.4 (11.2) | 22.5 1/59 | <0.0001 | Group | 7.6 2/208 | 0.0006 | |
| COMB | 107.8 (8.6) | 109.8 (11.5) | 1.8 1/57 | 0.2 | Visit × Group | 12.4 2/170 | <0.0001 | |
| BP diastolic | GUAN-IR | 65.5 (6.7) | 61.2 (9.3) | 12.9 1/54 | 0.0007 | Visit | 4.5 1/170 | 0.04 |
| DMPH | 64.3 (6.8) | 69.6 (9.0) | 25.5 1/59 | <0.0001 | Group | 5.6 2/208 | 0.004 | |
| COMB | 64.4 (6.7) | 67.5 (9.2) | 7.7 1/57 | 0.008 | Visit × Group | 19.0 2/170 | <0.0001 | |
| EKG QTc | GUAN-IR | 417.3 (20.0) | 415.3 (21.7) | 0.8 1/50 | 0.4 | Visit | 7.4 1/158 | 0.007 |
| DMPH | 416.3 (20.1) | 426.5 (21.1) | 11.9 1/53 | 0.001 | Group | 1.5 2/206 | 0.2 | |
| COMB | 417.4 (19.8) | 421.7 (21.6) | 2.6 1/55 | 0.1 | Visit × Group | 5.1 2/158 | 0.007 |
BP, blood pressure; COMB, combination; DMPH, dexmethylphenidate extended-release; EKG, electrocardiogram; GUAN, guanfacine immediate-release.