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. Author manuscript; available in PMC: 2016 Dec 22.
Published in final edited form as: J Pharm Sci. 2010 Apr;99(4):2018–2031. doi: 10.1002/jps.21970

Table 5.

AUC0–48 h of PC from Lymph Nodes Post-SC Injection into the Dorsal Surface of the Rat Footpad

PC ratio AUC0–48 h (mg h)/g
LPN Ratioa Cumulative Ratiob
LPN LIgN LIN LRN Cumulative
80:20 40.18 ± 5.27 20.48 ± 1.96 5.62 ± 0.71 11.05 ± 0.94 77.30 ± 8.88 1.0* 1.0*
50:50 96.15 ± 1.72 97.85 ± 6.11 34.63 ± 5.73 56.35 ± 4.75 284.98 ± 18.31 2.4* 3.7*
20:80 187.00 ± 14.18 302.90 ± 25.41 72.18 ± 8.81 215.60 ± 28.31 776.68 ± 76.71 4.7* 10.1*

n = 10; mean ± SEM.

*

Denotes statistical significance at p < 0.05.

a

Ratio of LPN AUC0–48 h of PC 80:20 and PC 50:50 to LPN PC 20:80 particles.

b

Ratio of cumulative AUC0–48 h of PC 80:20 and PC 50:50 to PC 20:80 particles.