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. Author manuscript; available in PMC: 2016 Dec 22.
Published in final edited form as: ACS Chem Biol. 2016 Jan 25;11(4):1012–1018. doi: 10.1021/acschembio.5b00899

Figure 2. Decreasing PD-1 by synthetic RORγt agonist.

Figure 2

Figure 2

a) IL17A, PD-1 and granzyme B mRNA expression in stimulated EL4 cells (activated with PMA/Ionomycin treatment for 5 hr). b) PD-1 surface expression in EL4 cells. Cells were pretreated with compound (desmosterol, SR0987) for 48 hr. c) intracellular staining of IL17A in TH17 cells. d) cell surface expression of PD-1. e) CD62L-PD1- cell population. f) PD-1 expression in human Jurkat T cells.