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Increase in the BBB leakage and hemorrhagic transformation. Large hyperintense areas on Gd-DTPA–enhanced MRI were observed 30 minutes after injection of Gd-DTPA in a rat treated with rhVEGF165 (b), compared with the precontrast image (a). A coronal section corresponding to the MRI section obtained at 24 hours after a stroke shows extensive Evans blue leakage and hemorrhage (c and d). Bar, 1 mm in d.
