FIG. 3.

Phase-specific gain or loss of methylation and the association with CGIs in disease versus control. a) Differentially methylated loci divided by gain or loss of methylation in proliferative phase in disease versus control. b) Differentially methylated loci divided by gain or loss of methylation in early secretory phase in disease versus control. c) Differentially methylated loci divided by gain or loss of methylation in midsecretory phase in disease versus control. Endo, endometriosis; green, loci with loss of methylation in disease compared with control; red, loci with gain of methylation in disease compared with control; hatched, loci in CGIs. In the proliferative phase, most of the differentially methylated loci in disease gained methylation, different from ESE and MSE. Also, most of the gain of methylation in PE in disease involved CGIs, whereas most of the loss of methylation in ESE and MSE involved CGIs.