Table 1.
Summary of the effect on HeLa cell of CDDP, α-M, and their combinations in the preincubation scheme. The table presents the combination index (CI) calculated based on the equation given in the text. ∗Mean values of three separate experiments performed in triplicate.
| Drugs in combination | Drugs alone | Control growth (%)∗ | Combination index | Interaction | ||
|---|---|---|---|---|---|---|
| CDDP μM (D 1) | α-M μM (D 2) | CDDP μM (D x1) | α-M μM (D x2) | |||
| 2 | 5 | 6.6 | 8.4 | 89.8 | 1.1 | |
| 2 | 10 | 20.7 | 13.8 | 73.0 | 0.8 | Synergistic |
| 5 | 10 | 25.4 | 14.8 | 68.0 | 1.0 | Additive |
| 2 | 15 | 37.9 | 16.5 | 56.1 | 1.0 | Additive |