Table 1.
The effects of HA + GA on CHF rats in H/B and LV dysfunction ().
Group | H/B (mg/g) | EF (%) | FS (%) |
---|---|---|---|
Sham | 0.30 ± 0.01 | 72.44 ± 0.63 | 43.35 ± 1.20 |
Model | 0.51 ± 0.02## | 92.29 ± 0.69## | 57.08 ± 1.30## |
Digoxin | 0.33 ± 0.01∗∗ | 77.40 ± 1.72∗ | 48.41 ± 0.91∗ |
HA | 0.48 ± 0.02 | 89.59 ± 1.48 | 54.71 ± 0.17 |
GA | 0.43 ± 0.01 | 86.69 ± 1.05∗ | 52.68 ± 0.58 |
HA + GA | 0.36 ± 0.01∗ | 80.56 ± 0.39∗∗ | 49.90 ± 0.73∗ |
Note: HA: hypaconitine; GA: glycyrrhetinic acid; H/B: the heart/body weight ratio; EF: ejection fraction; FS: fractional shortening. Sham group (n = 6), Model group (n = 6), Digoxin group (n = 6), HA group (n = 6), GA group (n = 7), and HA + GA group (n = 7). All data were presented as mean ± SD. ## P < 0.01 versus Sham group; ∗ P < 0.05 and ∗∗ P < 0.01 versus Model group.