TABLE 3.

Risk of Cancer in Children Conceived by ART Compared With Children Conceived Without ART, Norway, 1984–2011

Cancer Site	ICCC Site Group	Total Number of Tumors			Crude		Model IIa
		ART	Non-ART	Total	HR	95% CI	HR	95% CI
Leukemiab	I	17	1012	1029	1.52	0.94–2.45	1.67*	1.02–2.73
ALL	1a	9	768	777	1.03	0.53–1.98	1.16	0.60–2.27
AML	1b	5	173	178	2.65*	1.09–6.46	2.63*	1.04–6.64
Other leukemias	1c–e	3	71	74	4.91*	1.53–15.7	5.13*	1.50–7.60
Lymphomac	II	4	456	460	1.52	0.57–4.08	1.79	0.66–4.90
Hodgkin's	IIa	3	258	261	2.62	0.84–8.21	3.63*	1.12–11.72
Non-Hodgkin's	IIb	1	147	148	0.93	0.13–6.69	0.99	0.14–7.28
CNSc	III	12	1007	1019	1.25	0.71–2.21	0.92	0.47–1.79
Astrocytomas	IIIb	5	362	368	1.71	0.76–3.83	1.45	0.63–3.29
Embryonal CNS tumors	IIIc	3	175	179	2.13	0.79–5.74	1.70	0.62–4.69
Other gliomas	IIId	1	104	105	1.17	0.16–8.40	1.19	0.16–8.80
Other CNS tumors	IIIf	1	132	133	0.43	0.60–3.06	0.50	0.07–3.59
Neuroblastoma	IV	4	184	188	1.52	0.56–4.08	1.79	0.64–4.99
Retinoblastoma	V	1	90	91	0.75	0.10–5.38	—	—
Renal	VI	3	251	254	1.37	0.44–4.28	1.40	0.44–4.48
Hepatic	VII	2	108	110	2.22	0.54–9.07	1.76	0.41–7.46
Soft tissue	IX	5	307	312	1.69	0.70–4.09	1.33	0.54–3.30
Others	XI–XII	3	488	491	1.10	0.35–3.44	1.21	0.38–3.82
All		49	4414	4463	1.27	0.90–1.63	1.21	0.90–1.63

Cancers are classified by the third version of the ICCC. The proportional hazards assumption was tested with the Schoenfeld residuals.

^aAdjusted for birth year, birth order, maternal age at delivery, place of birth, gender, birth weight, and gestational age.

^bIn summing up the total number of cancers, each case of lymphoma and leukemia is counted only once.

^cAnalyses for sites with no cancer cases in the ART group were not performed and are therefore omitted from Table 3.

^*Significant HRs.