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. 2016 Dec 7;8(4):6580. doi: 10.4081/rt.2016.6580

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©Copyright Y Takanashi et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — A) An ill-defined tumor [hematoxylin and eosin (H&E) staining; magnification 12 × ] is predominantly occupied with lepidic growth structure. B) In the lepidic growth structure, an obvious invasive area, which was greater than 5mm in maximal diameter, was observed (H&E staining; magnification 200 ×). C) On higher magnification, the lepidic structure shows Clara type tumor cells with hobnail projections (H&E staining; magnification 400×). D) Innumerable isolated lepidic or papillary growth lesions detached from the main tumor (arrows) (H&E staining; magnification 12 ×). E) Some of these lesions locate close to peripheral bronchiole airways (arrow) (H&E staining; magnification 12x). F) These isolated lesions consist of Clara type tumor cells, that they are confirmed to be aerogenous metastases (H&E staining; magnification 400 ×).