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UV-B-induced skin tumor development in p53.S389A mice. (A) Mice were bred into a hairless background (SKH:HR7) and exposed to a daily UV-B radiation dose of 600 J/m2. Wild-type, ○; p53S389A/+, ▵; p53S389A/S389A, □; p53+/−, no symbol; wks, weeks. (B) Representative examples of squamous cell carcinoma and squamous cell papilloma, both isolated from UV-B-irradiated p53S389A/S389A mice.
