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. 2004 Oct;24(20):8872–8883. doi: 10.1128/MCB.24.20.8872-8883.2004

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Copyright © 2004, American Society for Microbiology

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FIG. 7. — Synaptic transmission in hippocampal slices. (A) Synaptic transmission. Baseline transmission at Schaffer collateral synapses in the CA1 area was measured at 25°C in hippocampal slices and was comparable between adult SynCre/LRP^lox/lox (open circles) and LRP^lox/lox (closed circles) mice. (B) Short-term synaptic plasticity was determined by paired-pulse facilitation in SynCre/LRP^lox/lox (open circles) and LRP^lox/lox (closed circles) mice and was unaffected by the loss of LRP1. (C) Hippocampal LTP was induced by two trains of a 1-s 100-Hz stimulation separated by 20 s (arrow) in SynCre/LRP^lox/lox (open circles) and LRP^lox/lox (closed circles) mice. No significant difference was observed. (D) SynCre/LRP^lox/lox mice were examined as described for panel C except that recombinant 10-μg/ml GST-RAP (closed circles) or 10-μg/ml GST (open circles) was added to the perfusion medium.