Table 5.

Adjusted Risk of Major Adverse Event

	Primary Analysis (not including death)		Secondary Analysis (including death)
Predictor	Odds Ratio (95% CI)	P value	Odds Ratio (95% CI)	P value
Annual Volume
<150	Reference		Reference
150-<300	0.55 (0.35, 0.86)	0.008	0.82 (0.59, 1.14)	0.24
300-<500	0.62 (0.41, 0.95)	0.03	0.73 (0.53, 1.01)	0.06
≥500	0.52 (0.31, 0.90)	0.02	0.78 (0.52, 1.15)	0.21
Procedure-type risk group
1	Reference		Reference
2	1.31 (1.06, 1.62)	0.01	1.86 (1.44, 2.39)	<0.001
3	1.57 (1.26, 1.96)	<0.001	1.76 (1.35, 2.31)	<0.001
4	2.03 (1.59, 2.61)	<0.001	2.03 (1.50, 2.77)	<0.001
Age
<30 days	Reference		Reference
≥30 days to ≤1 year	0.98 (0.77, 1.25)	0.89	0.89 (0.71, 1.11)	0.31
1≤18 years	0.86 (0.66, 1.11)	0.24	0.69 (0.55, 0.88)	0.002
>18 years	0.94 (0.69, 1.29)	0.72	0.82 (0.62, 1.08)	0.16
Genetic/Congenital condition	1.05 (0.86, 1.28)	0.64	1.36 (1.15, 1.59)	<0.001
History of CLD	0.86 (0.67, 1.12)	0.27	1.79 (1.49, 2.15)	<0.001
History of Renal Insufficiency	2.32 (1.77, 3.04)	<0.001	3.16 (2.50, 4.01)	<0.001
Single Ventricle	1.34 (1.15, 1.56)	<0.001	1.39 (1.22, 1.60)	<0.001
Pre-procedure sepsis	1.43 (0.88, 2.31)	0.15	1.50 (0.95, 2.38)	0.08
Need for Inotropes	1.75 (1.43, 2.14)	<0.001	2.58 (2.16, 3.08)	<0.001
Need for ECMO	1.09 (0.77, 1.54)	0.63	5.79 (4.22, 7.93)	<0.001
Need for LVAD	0.81 (0.19, 3.43)	0.77	2.97 (0.96, 9.25)	0.06
Procedure Status
Elective	Reference		Reference
Urgent	2.14 (1.78, 2.58)	<0.001	2.99 (2.55, 3.50)	<0.001
Emergent	3.51 (2.69, 4.57)	<0.001	4.42 (3.47, 5.63)	<0.001
Salvage	5.85 (3.37, 10.14)	<0.001	21.80 (11.95, 39.79)	<0.001
Saturation <95% (non-SV) or <78% (SV)
No	Reference		Reference
Yes	1.13(0.96, 1.33)	0.15	1.13 (0.98, 1.31)	0.08
Missing	1.11 (0.87, 1.41)	0.39	1.00 (0.80, 1.26)	0.97
MV Saturation <60% (non-SV) or <50% (SV)
No	Reference		Reference
Yes	1.80 (1.49, 2.18)	<0.001	1.85 (1.58, 2.18)	<0.001
Missing	1.31 (1.04, 1.64)	0.02	1.65 (1.35, 2.02)	<0.001
MPA Systolic Pressure ≥45 (non-SV) or MPA Mean Pressure ≥17mmHg (SV)
No	Reference		Reference
Yes	1.32 (1.09, 1.59)	0.004	1.99 (1.71, 2.32)	<0.001
Missing	1.42 (1.18, 1.71)	<0.001	1.27 (1.07, 1.51)	0.005
Systemic Ventricular EDP ≥ 18mmHg
No	Reference		Reference
Yes	1.48 (1.14, 1.94)	0.004	1.49 (1.18, 1.87)	<0.001
Missing	1.21 (1.04, 1.41)	0.02	1.13 (0.99, 1.30)	0.07

Abbreviations:CI, confidence interval; CLD, chronic lung disease; ECMO, extracorporeal membrane oxygenation; LVAD, left ventricular assist device; SV, single ventricle; MV, mixed venous; MPA, main pulmonary artery; EDP, end diastolic pressure