Table 6. Proportion of subjects in each treatment group meeting specified post-challenge endpoints and apparent efficacy versus Placebo (pooled data).
Treatment group | |||||||
---|---|---|---|---|---|---|---|
Placebo | 15 μg x 2 | 30 μg x 1 | 30 μg x 2 | ||||
N = 45 | N = 19 | N = 43 | N = 38 | ||||
Endpoint | No. subjects affected | No. subjects affected | Efficacy % | No. subjects affected | Efficacy % | No. subjects affected | Efficacy % |
Any Illness | 21 | 3* | 66.2 | 18 | 10.3 | 10 | 43.6 |
Any illness and seroconversion | 20 | 2* | 76.3 | 8* | 58.1 | 3* | 82.2 |
Systemic or lower respiratory illness and seroconversion | 16 | 1* | 85.2 | 5* | 67.3 | 2* | 85.2 |
Febrile illness and seroconversion | 9 | 0* | 100.0 | 3 | 65.1 | 0* | 100.0 |
Efficacy % = 1- [Attack rate (Vaccinated group)/(Attack rate(placebo group)]
* P<0.05