Table 2. Histopathology and immunohistochemistry of pituitary tissue specimens.
| No | Histological | Immunohistochemistry | |||||||
|---|---|---|---|---|---|---|---|---|---|
| diagnosis (H&E) | ACTH score | α-MSH score | GH | EGFRmem. | EGFRcyto. | EGFR nuc. | USP8cyto. | USP8nuc. | |
| 1 | Adenoma with cysts | 2 | 2 | - | 2 | 2 | 1 | 2 | 1 |
| 2 | Adenoma | 2 | 2 | - | 3 | 3 | 1 | 3 | 2 |
| 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 4 | Adenoma | 1 | 1 | - | 1 | 1 | 1 | 2 | 1 |
| 5 | Adenoma | 2 | 2 | - | 2 | 2 | 1 | 3 | 2 |
| 6 | Adenoma | 1 | 1 | - | 2 | 2 | 1 | 3 | 2 |
| 7 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 8 | Adenoma | 3 | 1 | - | 1 | 1 | 1 | 1 | 2 |
| 9 | Adenoma | 2.5 | 2.5 | - | 2 | 2 | 1 | 1 | 3 |
| 10 | Adenoma | 2.5 | 3 | - | NA | NA | NA | NA | NA |
| 11 | Adenoma | 2.5 | 2.5 | - | 3 | 2 | 1 | 3 | 2 |
| 12 | Adenoma with cysts | 3 | 2 | - | 3 | 3 | 1 | 2 | 2 |
| 13 | Infiltrative adenoma | 1 | 2.5 | - | 3 | 2 | 0 | 2 | 1 |
| 14 | Adenoma | 2.5 | 2.5 | - | NA | NA | NA | NA | NA |
| 15 | Adenoma with malignant characteristics | 0.5 | 0.5 | - | 1 | 1 | 0 | 2 | 0 |
| 16 | Adenoma | 3 | 1 | - | 2 | 1 | 0 | 2 | 2 |
| 17 | Adenoma | 3 | 2.5 | - | 3 | 3 | 0 | 2 | 2 |
| 18 | Adenoma | 2 | 3 | - | NA | NA | NA | NA | NA |
| 19 | Adenoma | 3 | 2 | - | 1 | 1 | 0 | 1 | 0 |
| 20 | Adenoma with malignant characteristics | 0.5 | 0.5 | - | 3 | 2 | 0 | 1 | 1 |
| 21 | Adenoma | 2 | 2 | - | 3 | 2 | 0 | 1 | 1 |
| 22 | Adenoma | 2 | NA | - | NA | NA | NA | NA | NA |
| 23 | Adenoma | 3 | NA | - | NA | NA | NA | NA | NA |
| 24 | Adenoma | 3 | 3 | - | 3 | 2 | 0 | 1 | 1 |
| 25 | Adenoma | 2 | 2 | - | 2 | 1 | 0 | 1 | 1 |
| 26 | Adenoma | 1 | 1 | - | NA | NA | NA | NA | NA |
| 27 | Adenoma | 3 | 2 | - | 2 | 1 | 0 | 1 | 3 |
| 28 | Adenoma with malignant characteristics | 3 | 2.5 | - | 3 | 2 | 0 | 2 | 2 |
| 29 | Adenoma | 2 | 2 | - | 2 | 1 | 0 | 1 | 3 |
| 30 | Adenoma | 3 | 2 | - | NA | NA | NA | NA | NA |
| 31 | Adenoma | 2 | 0 | - | NA | NA | NA | NA | NA |
| 32 | Adenoma | 1 | 2 | - | 3 | 2 | 0 | 2 | 2 |
| 33 | Adenoma | 3 | 2 | - | 3 | 2 | 0 | 1 | 2 |
| 34 | Adenoma | 1 | 1 | - | 1 | 1 | 0 | 2 | 1 |
| 35 | Adenoma | 2 | 2 | - | 3 | 2 | 0 | 1 | 1 |
| 36 | Adenoma | NA | NA | NA | NA | NA | NA | NA | NA |
| 37 | Adenoma | NA | NA | NA | NA | NA | NA | NA | NA |
| 38 | Adenoma | 0 | 0 | - | 0 | 0 | 0 | 1 | 1 |
ACTH = adrenocorticotropic hormone; α-MSH = α-melanocyte stimulating hormone; GH = growth hormone
USP8 = ubiquitin specific protease 8; EGFR = epidermal growth factor receptor
mem. = membrane; cyto. = cytoplasm; nuc. = nucleus.
NA = not available