Fig 4. Workflow for the identification of functional miRNA-mRNA interactions.

The workflow indicates the selection of small set of disease and phenotype specific functional targets from a large number of potential target genes for miR-629. In the first step miR-629 is connected with targets derived from databases of experimentally validated and predicted target genes (left). In the second step only those targets are preserved that are differentially expressed in prostate cancer (middle). Finally, functionally relevant miR-629 targets are determined based on a significant correlation between miR-629 and target gene expression (right).