Figure 6.

Subcellular localization of caspase-3 and nuclear factor-κB (NF-κB) in MCF-7 cells treated with compound VI (IC₂₅ and IC₅₀) for 24 h examined by confocal microscopy. Immunofluorescence staining of (A) caspase-3 and (B) NF-κB revealed cytoplasmic or nuclei localization in the cells, respectively. Treatment with compound VI had a a significant effect on the subcellular localization of caspase-3 and NF-κB in MCF-7 cells. ^**p<0.01 vs. VI IC₅₀ or IC₂₅ Con; ^#p<0.05 or ^##p<0.01 vs. fulvestrant (Fu).