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. 2016 Nov 22;39(1):113–125. doi: 10.3892/ijmm.2016.2809

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Copyright: © Xiong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Zinc protoporphyrin (ZnPP) inhibits heme oxygenase-1 (HO-1) enzymatic activity, but not its expression in the pancreas. Mice were divided into 5 groups (n=8 per group): normal control (NC), severe acute pancreatitis (SAP) model treated with vehicle (vehicle represents SAP control group), SAP model treated with luteolin (Lut), SAP model treated with ZnPP (ZnPP) and SAP model treated with luteolin plus ZnPP (Lut + ZnPP). Serum samples and pancreas were obtained for analysis at 6 h after modeling. (A) HO-1 activity in the pancreas (showed by concentration of its main catalysate bilirubin), (B) carbon monoxide (CO) contents in the pancreas (another catalyst of HO-1), (C) HO-1 mRNA levels, (D) serum HO-1 levels, (E) HO-1 protein levels, and (F) quantity of HO-1 protein normalized to β-actin. The results were similar in 3 independent experiments. Data are presented as the means ± SEM. ^aP<0.05 vs. NC group; ^bP<0.05 and ^bbP<0.01 vs. vehicle (SAP control group); ^ccP<0.01 vs. Lut group.