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. 2016 Nov 22;39(1):113–125. doi: 10.3892/ijmm.2016.2809

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Copyright: © Xiong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Heme oxygenase-1 (HO-1) inhibition by zinc protoporphyrin (ZnPP) reverses the protective effect of Luteolin (Lut). (A) Hematoxylin and eosin (H&E) staining, (B) pancreas wet/dry ratios, (C) pathological scores of pancreatic tissue, (D) serum amylase levels, (E) serum lipase levels, and (F) pancreatic myeloperoxidase (MPO) levels. The results were similar in 3 independent experiments. Data are presented as the means ± SEM. ^aaP<0.01 and ^aaaP<0.001 vs. normal control (NC) group; ^bbP<0.01 vs. vehicle [severe acute pancreatitis (SAP) control group]; ^cP< 0.05 and ^ccP< 0.01 vs. Lut group.