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. 2016 Nov 22;39(1):113–125. doi: 10.3892/ijmm.2016.2809

Figure 7.

Figure 7

Luteolin (Lut) improves the anti-inflammatory activity by suppressing heme oxygenase-1 (HO-1)-mediated nuclear factor-κB (NF-κB) signaling in the pancreas. (A) Interleukin-10 (IL-10) mRNA levels in the pancreas, (B) serum IL-10 levels, (C and D) expression of NF-κB p65 and its inhibiting protein IκBα in the pancreas, with β-actin and lamin B as internal references (left panel, western blot membranes; right panel, quantitative analysis of NF-κB p65 and IκBα normalized to β-actin and lamin B, respectively), (E) immunohistochemical analysis of NF-κB in the pancreas, and (F) quantification of NF-κB-positive cells in 5 independent immunohistochemical images. Data are presented as the means ± SEM. aP< 0.05, aaP<0.01 and aaaP<0.001 vs. NC group; bP<0.05 and bbP<0.01 vs. vehicle [severe acute pancreatitis (SAP) control group]; cP<0.05 and ccP<0.01 vs. Lut group.