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. 2016 Nov 16;39(1):21–30. doi: 10.3892/ijmm.2016.2804

Figure 4.

Figure 4

Effect of Humulus japonicus (HJ) on plaque deposition and tau phosphorylation in the brains of APP/PS1 transgenic (Tg-APP/PS1) mice. Photomicrographs showing anti-amyloid β (Aβ) antibody (Bam10)-stained cortex of (A) Tg-control (Tg-Con) mice and (B) HJ-treated Tg-APP/PS1 (Tg-HJ) mice. Scale bar, 100 µm. (C) Percentage area of cortex occupied by Bam10 immunoreactivity in the vehicle-treated Tg-APP/PS1 control mice and HJ-treated Tg-APP/PS1 mice. Photomicrographs showing anti-phospho-tau antibody (AT8)-stained cortex of (D) vehicle-treated Tg-APP/PS1 control mice and (E) HJ-treated Tg-APP/PS1 mice. Scale bar, 100 µm. (F) Percentage area of cortex occupied by AT8 immunoreactivity in the vehicle-treated Tg-APP/PS1 control mice and HJ-treated Tg-APP/PS1 mice. *p<0.05 and **p<0.01, significant differences from Tg-control, as shown by the Student's t-test. Data are presented as the means ± SEM.