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. 2016 Nov 16;39(1):21–30. doi: 10.3892/ijmm.2016.2804

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Copyright: © Park et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of Humulus japonicus (HJ) on APP processing and degrading enzyme. Western blot analysis and quantitative analysis for (A–E) APP and APP metabolites and (F–I) a disintegrin and metalloproteinase 10 (ADAM10), β-site APP-cleaving enzyme 1 (BACE1), neprilysin (NEP) and insulin degrading enzyme (IDE) in the cortex homogenates of non-Tg control (Non-Tg), vehicle-treated APP/PS1 transgenic (Tg-APP/PS1) control (Tg-Con), and HJ-treated Tg-APP/PS1 (Tg-HJ) mice. ^*p<0.05, significant differences from Tg-control, as shown by the Student's t-test. Data are presented as the means ± SEM.