Table 2.
Genotype frequencies of TLR-9 gene polymorphisms in colorectal cancer and controls
| Gene | SNP ID | Genotype | Case, n (%) | Control, n (%) | OR | 95% CI | χ2 value | P-value |
|---|---|---|---|---|---|---|---|---|
| TLR-9 | rs187084 | CC | 47 (0.43) | 34 (0.35) | Ref | |||
| CT | 47 (0.43) | 53 (0.53) | 0.642 | 0.355–1.158 | 2.18 | 0.13991 | ||
| TT | 15 (0.14) | 12 (0.12) | 0.904 | 0.376–2.176 | 0.05 | 0.82221 | ||
| CT + TT | 62 (0.57) | 65 (0.65) | 0.690 | 0.393–1.210 | 1.68 | 0.19487 | ||
| C | 141 (0.65) | 121 (0.61) | Ref | |||||
| T | 77 (0.35) | 77 (0.39) | 0.858 | 0.576–1.278 | 0.57 | 0.45166 | ||
| rs352139 | AA | 33 (0.29) | 31 (0.30) | Ref | ||||
| AG | 55 (0.49) | 55 (0.54) | 0.939 | 0.507–1.740 | 0.04 | 0.84243 | ||
| GG | 26 (0.23) | 16 (0.16) | 1.527 | 0.691–3.372 | 1.10 | 0.29448 | ||
| AG + GG | 81 (0.71) | 71 (0.70) | 1.072 | 0.597–1.923 | 0.05 | 0.81642 | ||
| A | 121 (0.54) | 117 (0.57) | Ref | |||||
| G | 107 (0.48) | 87 (0.43) | 1.189 | 0.813–1.740 | 0.80 | 0.37163 | ||
| rs352144 | AA | 2 (0.02) | 0 (0) | Ref | ||||
| AC | 5 (0.04) | 7 (0.07) | 0.147 | 0.006–3.706 | 2.33 | 0.12663 | ||
| CC | 110 (0.94) | 94 (0.93) | 0.234 | 0.011–4.932 | 1.70 | 0.19294 | ||
| AC + CC | 115 (0.98) | 101 (1) | 0.228 | 0.011–4.796 | 1.74 | 0.18682 | ||
| A | 9 (0.04) | 7 (0.03) | Ref | |||||
| C | 225 (0.96) | 195 (0.97) | 0.897 | 0.328–2.455 | 0.04 | 0.83298 |
Abbreviations: CI, confidence interval; OR, odds ratio; Ref, reference; SNP, single-nucleotide polymorphism.