Table 4B.
Genotype frequencies of TLR-9 gene polymorphism in female patients with colorectal cancer
| Gene | SNP ID | Genotype | Case, n (Frequency in %) |
Control, n (Frequency in %) |
OR | 95% CI | χ2 value | P-value |
|---|---|---|---|---|---|---|---|---|
| TLR-9 | rs187084 | CC | 25 (0.54) | 15 (0.37) | Ref | |||
| CT | 17 (0.37) | 18 (0.44) | 0.567 | 0.225–1.424 | 1.47 | 0.22539 | ||
| TT | 4 (0.09) | 8 (0.19) | 0.300 | 0.077–1.169 | 3.18 | 0.07439 | ||
| CT + TT | 21 (0.46) | 26 (0.63) | 0.485 | 0.205–1.146 | 2.75 | 0.09703 | ||
| C | 67 (0.73) | 48 (0.59) | Ref | |||||
| T | 25 (0.27) | 34 (0.41) | 0.527 | 0.279–0.995 | 3.95 | 0.04686 | ||
| rs352139 | AA | 14 (0.28) | 15 (0.36) | Ref | ||||
| AG | 24 (0.48) | 21 (0.50) | 1.224 | 0.481–3.118 | 0.18 | 0.67089 | ||
| GG | 12 (0.24) | 6 (0.14) | 2.143 | 0.632–7.266 | 1.52 | 0.21765 | ||
| AG + GG | 36 (0.72) | 27 (0.64) | 1.429 | 0.591–3.454 | 0.63 | 0.42761 | ||
| A | 52 (0.52) | 51 (0.61) | Ref | |||||
| G | 48 (0.48) | 33 (0.39) | 1.427 | 0.792–2.568 | 1.41 | 0.23559 | ||
| rs352144 | AA | 0 (0) | 0 (0) | Ref | ||||
| AC | 4 (0.08) | 4 (0.1) | 1.000 | 0.016–62.3 | – | 1.000 | ||
| CC | 46 (0.92) | 38 (0.9) | 1.208 | 0.023–62.29 | – | 1.000 | ||
| AC + CC | 50 (1) | 42 (1) | 1.188 | 0.023–61.16 | – | 1.000 | ||
| A | 4 (0.04) | 4 (0.05) | Ref | |||||
| C | 96 (0.96) | 80 (0.95) | 1.200 | 0.291–4.951 | 0.06 | 1.000 |
Note: Bold values are statistically significantly different.
Abbreviations: CI, confidence interval; OR, odds ratio; Ref, reference; SNP, single-nucleotide polymorphism.