Table 5B.
Genotype frequencies of TLR-9 gene polymorphisms in colorectal cancer tumors located in rectal area
| Gene | SNP ID | Genotype | Case, n (Frequency in %) |
Control, n (Frequency in %) |
OR | 95% CI | χ2 value | P-value |
|---|---|---|---|---|---|---|---|---|
| TLR-9 | rs187084 | CC | 14 (0.42) | 34 (0.35) | Ref | |||
| CT | 15 (0.46) | 53 (0.53) | 0.687 | 0.295–1.602 | 0.76 | 0.38390 | ||
| TT | 4 (0.12) | 12 (0.12) | 0.810 | 0.223–2.945 | 0.10 | 0.74819 | ||
| CT + TT | 19 (0.58) | 65 (0.65) | 0.710 | 0.317–1.588 | 0.70 | 0.40332 | ||
| C | 43 (0.65) | 121 (0.61) | Ref | |||||
| T | 23 (0.35) | 77 (0.39) | 0.841 | 0.470–1.503 | 0.34 | 0.55786 | ||
| rs352139 | AA | 6 (0.18) | 31 (0.30) | Ref | ||||
| AG | 17 (0.50) | 55 (0.54) | 1.597 | 0.570–4.471 | 0.80 | 0.37026 | ||
| GG | 11 (0.32) | 16 (0.16) | 3.552 | 1.11–11.37 | 4.81 | 0.02825 | ||
| AG + GG | 28 (0.82) | 71 (0.70) | 2.038 | 0.767–5.415 | 2.09 | 0.14812 | ||
| A | 29 (0.43) | 117 (0.57) | Ref | |||||
| G | 39 (0.57) | 87 (0.43) | 1.809 | 1.038–3.150 | 4.44 | 0.03519 | ||
| rs352144 | AA | 1 (0.03) | 0 (0) | Ref | ||||
| AC | 1 (0.03) | 7 (0.07) | 0.067 | 0.002–2.563 | 3.94 | 0.04722 | ||
| CC | 33 (0.94) | 94 (0.93) | 0.118 | 0.005–2.972 | 2.79 | 0.09506 | ||
| AC + CC | 34 (0.97) | 101 (1) | 0.113 | 0.005–2.847 | 2.91 | 0.08819 | ||
| A | 3 (0.04) | 7 (0.03) | Ref | |||||
| C | 67 (0.96) | 195 (0.97) | 0.802 | 0.202–3.189 | 0.10 | 0.73581 |
Note: Bold values are statistically significantly different.
Abbreviations: CI, confidence interval; OR, odds ratio; Ref, reference; SNP, single-nucleotide polymorphism.