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3D response surface plot illustrating the effect of autonomous variables on CQAs.
Notes: (A) Effect of sonication time and PVP on particle size; (B) Effect of PVA and PVP on particle size; (C) Effect of sonication time and PVP on PDI; (D) Effect of PVP and PVA on PDI; and (E) Effect of PVA and PVP on zeta potential.
Abbreviations: PDI, polydispersity index; CQAs, critical quality attributes; 3D, three-dimensional; PVA, polyvinyl alcohol; PVP, polyvinylpyrrolidone.
