Table 2.
Optimized CMAs and CPPs and verified CQAs
| Response parameters | CMAs/CPPs
|
CQAs
|
||||
|---|---|---|---|---|---|---|
| Sonication time (min) | Concentration of PVP (% w/v) | Concentration of PVA (% w/v) | Particle size (nm) | Polydispersity index | Zeta potential | |
| Software-predicted results | 15 | 1.031 | 2.959 | 249.80 | 0.395 | −5.43 |
| Actual obtained results | 15 | 1 | 3 | 248.20 | 0.391 | −5.62 |
| Residual values (%) | – | – | – | 0.64 | 1.01 | −3.49 |
Abbreviations: CMAs, critical material attributes; CPPs, critical processing parameters; CQAs, critical quality attributes; PVA, polyvinyl alcohol; PVP, polyvinylpyrrolidone.