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. 2016 Dec 22;11(12):e0168845. doi: 10.1371/journal.pone.0168845

Fig 8. TEM image showing mitochondrial structure in HCFs, T1DMs, and T2DMs, when cultured in our 3D model.

Fig 8

(A) HCFs: Mitochondria appeared normal, with a double membrane, discrete cristae and little internal space. (B) T1DMs: Mitochondria appeared condensed and showed expanded internal spaces. (C) T2DMs: Smaller mitochondrial structure, dilated vacuoles and presence of endoplasmic reticulum were witnessed. (D) Quantification analysis of abnormal mitochondria cells percentage in HCF, T1DM, and T2DM constructs. The data is representative of 4 independent experiments, n = 4 (* = p≤0.05; ** = p≤0.01; *** = p≤0.001; **** = p≤0.0001). Scale bars = 500nm.