Table 1.

APH(3′)-IIIa-catalyzed phosphorylation rates determined at the same concentration for all paromomycin analogues.

Compd	R	v0[a] [nM s−1]	Compd	R	v0[a] [nM s−1]
3	H	54.9	26		7.6
14		9.1	27		8.7
15		12.2	28		9.5
16		8.3	29		11.1
17		9.8	30		10.9
18		ND[b]	31		6.8
19		6.4	32		5.6
20		ND[b]	33		ND[b]
21		7.0	34		5.4
22		8.3	35		ND[b]
23		6.2	36		6.6
24		7.2	37		11.7
25		5.4	38		5.2

^[a]v₀ : initial phosphorylation rate;

^[b]ND: not detectable.