. Author manuscript; available in PMC: 2016 Dec 22.

Published in final edited form as: ChemMedChem. 2011 Sep 8;6(11):1961–1966. doi: 10.1002/cmdc.201100346

Table 3.

Inhibition (IC₅₀) of APH (3′)-IIIa by paromomycin analogues functionalized at the O2″ position.^[a]

Compd	IC₅₀ [μM]	Compd	IC₅₀ [μM]
14	17.2 ± 2.3	27	30.3 ± 5.6
15	30.6 ± 5.7	28	37.1 ± 3.5
16	2.0 ± 0.2	29	6.0 ± 0.7
17	4.3 ± 0.5	30	2.3 ± 0.3
18	12.3 ± 1.7	31	12.4 ± 1.9
19	16.1 ± 2.5	32	21.1 ± 1.6
20	9.5 ± 0.7	33	2.8 ± 0.3
21	18.5 ± 1.8	34	39.2 ± 7.3
22	24.2 ± 4.5	35	5.5 ± 0.1
23	11.7 ± 0.1	36	4.3 ± 0.5
24	3.1 ± 0.4	37	12.7 ± 1.6
25	16.0 ± 2.0	38	2.2 ± 0.3
26	5.0 ± 0.7

^[a]

Values represent the mean ± SD of n =3 experiments.