Table 4.
Antibacterial activities of compound 20 and other aminoglycosides (3, 4, 9, 10 and 13) against a variety of different bacterial strains.
| Species | Phenotype | 20 | 3[a] | 4[a] | 9 | 10 | 13 |
|---|---|---|---|---|---|---|---|
| MIC [μg mL−1] | |||||||
| Staphylococcus aureus | ATCC 29213 | 0.5 | 2 | 0.5 | 0.5 | 0.5 | 4 |
| Escherichia coli | ATCC 25922 | 4 | 2 | 1 | 0.5 | 1 | 2 |
| Klebsiella pneumoniae | ATCC 10031 | 2 | 2 | 0.25 | 0.25 | 0.5 | 0.25 |
| Pseudomonas aeruginosa | ATCC 27853 | >64 | >64 | 64 | 0.5 | 0.5 | 2 |
| P. aeruginosa | Wild-type pump | >64 | >64 | 8 | 1 | 0.5 | 2 |
| Acinetobacter baumannii | Susceptible | 2 | 2 | 1 | 0.5 | 0.5 | 2 |
| P. aeruginosa | MexXY up | >64 | >64 | 16 | 4 | 0.5 | 4 |
| A. baumannii | ATCC 19606 | >64 | 16 | 4 | 8 | 4 | 16 |
| P. aeruginosa | Efflux | >64 | >64 | > 64 | 4 | 2 | 16 |
| P. aeruginosa | Efflux | >64 | >64 | > 64 | 8 | 2 | 32 |
| Providencia stuartii | AAC(2′)-I | >64 | >64 | 32 | 64 | 32 | 4 |
| E. coli | APH(3′)-Ib | >64 | >64 | > 64 | 0.25 | 1 | 0.5 |
| S. aureus | APH(3′)-III | >64 | >64 | > 64 | 0.5 | 1 | 8 |
| A. baumannii | ANT(2″)-I, APH(3′)-VI, Perm/Efflux | >64 | >64 | > 64 | >64 | >64 | > 64 |
| Acinetobacter spp. | APH(3′)-VI | >64 | >64 | 16 | 0.5 | 1 | > 64 |
| S. aureus | ANT(4′)-I | >64 | >64 | > 64 | 0.5 | >64 | > 64 |
| P. aeruginosa | ANT(4′)-II | >64 | >64 | 8 | 1 | 64 | 64 |
| Serratia marcescens | AAC(6′)-I | 8 | 4 | 4 | 2 | 64 | 64 |
| P. aeruginosa | AAC(6′)-I | >64 | >64 | > 64 | 64 | >64 | > 64 |
| P. aeruginosa | AAC(6′)-II | >64 | >64 | 8 | 64 | 32 | 4 |
| E. coli | ANT(2″)-I | 8 | 8 | 2 | >64 | >64 | 4 |
| Enterobacter cloacae | AAC(6′)-I, ANT(2″)-I, APH(3′)-I | >64 | >64 | > 64 | >64 | >64 | 64 |
| S. aureus | AAC(6′)-I, APH(2″) | >64 | >64 | > 64 | >64 | >64 | > 64 |
| P. aeruginosa | AAC(3)-I | >64 | >64 | 8 | 64 | 0.5 | 4 |
| E. coli | AAC(3)-IV | 16 | 16 | 8 | 32 | >64 | 2 |
[a]
Paromomycin (3); neomycin B (4).