Table 3. Diagnostic test characteristics of the serial mode combinations among screening tools*.
| Combination among tests | Sensitivity (%) | Specificity (%) | Youden Index (%) | PPV, % (95% CI) | NPV, % (95% CI) | AUC, (95% CI) |
|---|---|---|---|---|---|---|
| MMSE + Mini-Cog | 83.11 (81.34–85.32) | 91.22 (79.04–93.39) | 74.33 (72.13–76.39) | 72.78 (70.48–75.92) | 95.03 (93.83–98.74) | 87.23 (85.02–89.31) |
| MMSE + AD8 | 84.46 (82.34–86.93) | 88.92 (86.43–91.03) | 73.38 (71.83–75.58) | 68.31 (76.03–72.47) | 95.29 (93.36–98.17) | 86.71 (84.52–88.83) |
| MMSE + CDT | 84.91 (82.21–86.43) | 90.44 (88.72–92.13) | 75.35 (73.02–78.24) | 71.54 (68.93–73.38) | 95.49 (93.37–97.42) | 87.72 (85.62–89.83) |
| Mini-Cog + AD8 | 81.53 (79.21–83.45) | 91.92 (89.03–93.28) | 73.45 (71.93–75.43) | 74.03 (72.34–77.04) | 94.63 (92.57–96.64) | 86.73 (84.51–89.04) |
| Mini-Cog + CDT | 85.59 (82.94–87.43) | 87.89 (85.39–90.30) | 73.48 (71.23–75.42) | 66.67 (64.93–69.06) | 95.56 (93.53–97.39) | 86.74 (84.62–88.83) |
| AD8 + CDT | 82.66 (80.39–84.43) | 90.69 (88.03–92.26) | 73.35 (71.28–75.04) | 71.54 (68.74–74.93) | 94.87 (92.51–97.03) | 86.71 (84.53–88.92) |
| MMSE + Mini-Cog + AD8 + CDT | 76.58 (74.32–78.93) | 94.07 (92.32–96.23) | 70.65 (68.04–73.08) | 78.52 (76.86–81.28) | 93.42 (91.32–96.07) | 85.34 (82.91–87.80) |
*Positive when all tests were positive and negative otherwise.