Table 2. Single-arm synthesis.

Group	Study (n)	Patient (n)	Biopsy (n)	Sensitivity (95% CI) (%)	Specificity (95% CI) (%)	DOR	AUC (%)
Original pathological criteria
WLB	39	4,356	11,587	54 [46–61]	79 [73–84]	4 [3–6]	72 [68–76]
AFB	39	4,027	11,149	87 [82–90]	65 [58–72]	13 [8–19]	85 [81–87]
AFB + WLB	17	3,208	9,150	88 [82–93]	59 [48–68]	11 [6–19]	82 [78–85]
NBI	6	344	1,061	96 [78–99]	84 [70–92]	131 [35–490]	94 [91–96]
Moderate dysplasia, severe dysplasia, CIS and invasive carcinoma
WLB	10	1,153	3,353	51 [34–68]	86 [75–93]	6 [3–13]	77 [73–81]
AFB	7	896	1,937	93 [77–98]	52 [37–67]	15 [4–57]	76 [72–79]
AFB + WLB	7	1,125	3,315	86 [75–97]	71 [56–87]	16 [6–41]	82 [78–85]
NBI	1	22	64	100	43	–	–

Data in parentheses are 95% CIs. WLB, white light bronchoscopy; AFB, autofluorescence bronchoscopy; AFB + WLB, AFB combined with WLB; NBI, narrow-band imaging; DOR, diagnostic odds ratio; AUC, area under the receiver-operating characteristic curve; CIS, carcinoma in situ.