Table 3. Direct comparison.
| Group | Study (n) | Patient (n) | Biopsy (n) | Technique | Sensitivity (95% CI) (%) | P | Specificity (95% CI) (%) | P | DOR (95% CI) | P | AUC (95% CI) (%) | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Original pathological criteria | ||||||||||||
| WLB versus AFB | 30 | 2,492 | 6,062 | WLB | 51 [42–60] | <0.001 | 79 [72–85] | 0.002 | 4 [3–5] | <0.001 | 71 [67–75] | <0.001 |
| AFB | 86 [82–90] | 62 [54–70] | 10 [7–15] | 84 [81–87] | ||||||||
| WLB versus AFB + WLB | 14 | 2,578 | 7,813 | WLB | 51 [35–66] | <0.001 | 83 [75–89] | <0.001 | 5 [3–9] | 0.126 | 77 [74–81] | 0.083 |
| AFB + WLB | 88 [80–93] | 57 [45–68] | 10 [5–19] | 82 [78–85] | ||||||||
| WLB versus NBI | 3 | 154 | 226 | WLB | 29 [17–44] | <0.001 | 82 [74–88] | 0.043 | 2 [1–6] | 0.008 | 66 [47–85] | 0.030 |
| NBI | 79 [65–90] | 71 [62–78] | 19 [7–52] | 89 [82–96] | ||||||||
| Moderate dysplasia, severe dysplasia, CIS and invasive carcinoma | ||||||||||||
| WLB versus AFB | 6 | 728 | 1,549 | WLB | 50 [25–75] | 0.009 | 83 [64–93] | 0.009 | 5 [2–12] | 0.393 | 75 [71–79] | 0.271 |
| AFB | 88 [74–95] | 50 [33–66] | 7 [4–12] | 76 [72–80] | ||||||||
| WLB versus AFB + WLB | 5 | 862 | 2,727 | WLB | 46 [20–73] | 0.062 | 91 [87–94] | <0.001 | 9 [3–24] | 0.413 | 89 [86–92] | <0.001 |
| AFB + WLB | 85 [54–97] | 71 [57–82] | 14 [4–51] | 81 [77–84] | ||||||||
| WLB versus NBI | 1 | 22 | 64 | WLB | 62 | – | 65 | – | – | – | – | – |
| NBI | 100 | 43 | – | – | ||||||||
WLB, white light bronchoscopy; AFB, autofluorescence bronchoscopy; AFB + WLB, AFB combined with WLB; NBI, narrow-band imaging; DOR, diagnostic odds ratio; AUC, area under the receiver-operating characteristic curve; CIS, carcinoma in situ.