Table 1. Ongoing clinical trials.
Trail number | Institution | SBRT dose (Gy)/fraction | Target organs | Immunotherapy drug | Treatment order | Phase |
---|---|---|---|---|---|---|
NCT01950195 | Johns Hopkins University | NS | Brain, spine | Ipilimumab | Immunotherapy, then SABR, then immunotherapy | I |
NCT01497808 | University of Pennsylvania | NS | NS | Ipilimumab | SABR then immunotherapy | I/II |
NCT02239900 | MD Anderson Cancer Center | 50/4 or 60/10 | Liver, lung, adrenal | Ipilimumab | Concurrent; or immunotherapy then SABR | I/II |
NCT01862900 | Chiles Research Institute | 15/1 or 20/1 | Lung, liver | Anti-OX40 | Concurrent | I/II |
NCT01769222 | Stanford University | 20/2 | Any | Ipilimumab | Concurrent | I/II |
NCT01401062 | New York University | 22.5/3 | Any | Fresolimumab | Concurrent | I/II |
NCT02298946 | NIH/NCI | 8/1 or 24/3 | Liver | PD-1 inhibitor | SABR then immunotherapy | I |
NCT01703507 | Thomas Jefferson University | 24/1 or 21/1 or 18/1 or 15/1 | Brain | Ipilimumab | Concurrent | I |
NCT02444741 | MD Anderson Cancer Center | 50/4 | Lung, liver | PD-1 inhibitor |
NCI, National Cancer Institute; SBRT, stereotactic body radiotherapy; NS, not specified; PD-1, programmed cell death protein 1.